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Side effects of Ozempic 

By Dr Naveed Asif

As a General Practitioner, it’s essential for me to discuss the use of Ozempic (semaglutide) with my patients, especially regarding its potential side effects. Ozempic is a GLP-1 receptor agonist that can be effective for managing type 2 diabetes and assisting with weight loss, but there are some serious concerns we need to keep in mind.

1. What are the most concerning side effects of Ozempic?

Some of the more serious side effects include nausea, vomiting, and diarrhoea, which can be quite uncomfortable. There’s also a risk of pancreatitis, kidney issues, and even an increased likelihood of thyroid tumors, particularly a type called medullary thyroid carcinoma. Furthermore, I want to highlight the risk of diabetic ketoacidosis (DKA), especially if insulin is suddenly stopped or reduced too quickly. While we haven’t seen reports of DKA linked to semaglutide in the UK yet, we need to remain cautious.

2. Why are they particularly concerning?

These side effects can lead to significant health problems. For example, pancreatitis can cause severe abdominal pain, which might require hospitalisation. The concerns about thyroid tumors and the potential for DKA are particularly worrisome, as they can have serious long-term effects on health. Additionally, the gastrointestinal side effects can impact your daily life and make it hard to stick with the treatment. Persistent nausea and vomiting can lead to dehydration and kidney damage, which is another reason why monitoring is crucial.

3. How likely is it that Ozempic users will experience these side effects?

The chances of experiencing side effects vary from person to person. Nausea and vomiting are fairly common, affecting about 20-30% of users, especially during the first few weeks of treatment. Serious issues like pancreatitis are less frequent, occurring in roughly 0.5% of users. While we currently have no reports of DKA associated with semaglutide, it’s important to take the history of other GLP-1 receptor agonists into account. I always advise starting with a lower dose and gradually titrating up to help minimise the risk of serious side effects and allow your body to adjust to the medication. Careful, gradual reduction of insulin doses and close monitoring of blood glucose levels are also essential. It’s crucial for patients to be aware of the symptoms of DKA so that they can seek medical help promptly if needed.

Additionally, I want to stress the importance of obtaining Ozempic from reputable sources. There have been instances of falsified products in the UK that can pose serious health risks. Patients should always get their prescriptions from qualified healthcare providers and be vigilant for signs of hypoglycemia, especially if they suspect they might have received a counterfeit medication.

Lastly, I make it a point to discuss the potential side effects of GLP-1 receptor agonists with my patients and stress the importance of staying hydrated, recognising serious side effects, and ensuring they’re getting their prescriptions through authorised channels.

Ozempic Feet (The Standard)

Ozempic has gained considerable recognition as a weight loss medication. With rapid weight loss, patients may experience foot-related side effects, similar to those affecting other parts of the body.

However, the term “Ozempic feet” is not one I am familiar with or have historically used in my practice.

While side effects can occur, it’s challenging to assess how common they are, especially since many may manifest over the long term. Semaglutide has only recently received approval for weight loss and has been widely promoted through word-of-mouth, social media, and mainstream news. As such, there is still limited data on chronic side effects, particularly those related to the feet, which may develop over several months to years.

Patients should be aware of potential symptoms that could indicate issues with blood sugar management or unhealthy weight loss, necessitating a consultation with your doctor. Taking Ozempic can affect the feet in various ways, including:

  • Peripheral Neuropathy: This condition involves damage to the nerves, leading to symptoms such as numbness, tingling, or pain in the feet.
  • Skin Reactions: Some patients have reported skin rashes or allergic reactions that can affect the feet.
  • Circulation Issues: Metabolic changes may impact blood vessels and circulation, potentially resulting in swelling or discomfort in the feet.
  • Foot Ulcers: It’s crucial for diabetes management to prevent complications such as ulcers, which can arise due to nerve damage and circulation problems.

In terms of how common these side effects are, gastrointestinal issues like nausea, vomiting, and abdominal pain are among the most frequently reported side effects, with nausea affecting about almost a fifth of patients. While many side effects tend to be temporary, some can be quite severe. Feet-associated side effects data is still limited, and I would be unable to comment on its frequency – This will change over the coming years as we gain more long-term insight and data into Semglutide.

Patients need to be especially vigilant for specific foot-related symptoms, included below and, if present, it is crucial to seek medical attention immediately:

  • Pain or Numbness: Any changes in sensation or persistent pain in the feet may indicate nerve damage.
  • Swelling: New, unexplained swelling or discomfort in the feet, especially if it persists.
  • Skin Changes: Any rash, sore, or changes in colour or temperature of the feet .
  • Signs of Infection: Symptoms such as redness, warmth, or discharge from cuts or sores on the feet may indicate an infection.
  • Persistent Gastrointestinal Issues: Ongoing nausea or vomiting can impact overall health and blood sugar control and should be addressed promptly

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